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KMID : 0895820230330010001
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Journal of Oriental Rehabilitation Medicine
2023 Volume.33 No. 1 p.1 ~ p.12
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The Study on Anti-Oxidant and Anti-Inflammatory Effects of Wolbigachul-tang
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Im Seung-Kyu
Sul Jae-Uk
Kim Seon-Jong
Jeong Jae-Min
Seon Yun-Gwon
Choi Jin-Bong
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Abstract
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Objectives This study was conducted to find out the antioxidant and inflammatory improvement effects of Wolbigachul-tang.
Methods To evaluate the antioxidant and anti-inflammatory effects of wolbigachul- tang, the total polyphenol and flavonoid contents were measured. And radical scavenging function was measured. In addition reactive oxygen species, nitric oxide, cytokines productions were measured by treating wolbigachul-tang in the lipopolysaccharide- induced RAW264.7 cells. We also measured the gene expression of inducible nitric oxide synthase, cyclooxygenase-2, cytokines too.
Results Radical scavenging experiments showed significant concentration-dependent scavenging capacity increase. The amount of reactive oxygen species, nitric oxide, cytokines production in the cell all showed a significant concentration-dependent decrease compared to the control group. The gene expression of inducible nitric oxide synthase, cyclooxygenase-2, and cytokines also showed a significant concentration- dependent decrease compared to the control group.
Conclusions In conclusion, it is believed that wolbigachul-tang can be applied to various inflammatory diseases.
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KEYWORD
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Wolbigachul-tang, Antioxidants, Anti-inflammatory
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